I Have A Super USB Drive

The next day, in the Zhongzhou Academy of Sciences-Shangdu Institute of Life Sciences.

Around seven in the morning, five or six male and female employees were wiping tables and chairs in a venue while chatting about things on the Internet in their spare time at work.

Because it was not yet time to go to work, the crisp laughter of girls came from the venue from time to time, bringing a fresh breath to the quiet and solemn institute.

Until 7:30, everyone wiped away the dust that fell in the venue and began to wipe the windows and railings.

"Why haven't you finished yet?"

At this moment, a middle-aged man in a neat suit rushed in with a face full of urgency, "Hurry up, this venue will be used at eight o'clock!"

"Team leader, don't worry, it can be cleaned before eight o'clock." A young girl replied with a smile, "Why are you in such a hurry."

"What do you know?"

The middle-aged man looked even more anxious, "I just received the news that there are the dean and the vice dean who came to this venue. Don't you know that the dean is used to arriving ten minutes earlier?"

Everyone was startled, and quickly accelerated the movements in their hands.

Just when the middle-aged man was in a hurry, and even prepared to roll up his sleeves, there was a sudden sound of footsteps behind him.

The middle-aged man turned his head subconsciously, but saw a young man in a white shirt approaching, "Excuse me, is this the meeting room No. 3?"

"Yes, may I ask who you are?" The middle-aged man saw that the young man was a little confused and realized that he was not from the hospital, so he subconsciously glanced at the work card on the other side's neck.

Chen Chen?

never heard of it...

"I'm the speaker at this meeting." The young man named Chen Chen glanced inside, "Can I go in now? I want to prepare in advance."

"Oh, yes, please come in..."

The middle-aged man quickly stepped aside, watching the young man walk up to the podium skillfully and start debugging the projection equipment, he couldn't help being a little surprised.

It was the first time he had seen such a young face standing on that podium, not to mention, this time it was the Dean himself.

Everyone who cleaned the venue looked at the young man curiously, but did not dare to continue chatting, and the movements in their hands sped up a bit, but the venue was cleaned up in about ten minutes.

Only then did the middle-aged man breathe a sigh of relief. He finally glanced at the podium. Seeing that the young man was still checking the PPT with a serious face, he made a gesture to everyone and prepared to leave the venue.

However, just as he was about to leave with everyone silently, his heart suddenly tightened.

I saw that in the corridor, the dean and a large number of academicians were already walking here from a distance.

"Let's go!" The middle-aged man hurriedly shouted at the crowd, and the group quickly left.

After a few minutes.

Inside the venue, a group of men dressed in work clothes and with different expressions filed in. Although they had not yet started their speeches, these people still sat quietly in their seats, showing excellent qualities.

These people are not students, but a group of middle-aged and elderly people over fifty, and some even over sixty.

However, unlike ordinary middle-aged and elderly people, everyone here is at the top level in the academic world, and several of them are famous all over the world.

These people are basically academicians of the Chinese Academy of Sciences, and the others are also senior managers like Wang Luo.

What Chen Chen had to do was to convince the top elites in the academic world, because only when these people admitted the feasibility of Chen Chen's plan would be an explanation to the government, and Professor Wang Xi would agree to go abroad for treatment.

Looking at the already full venue,

Chen Chen bowed slightly, and began to speak in a long breath:

"The so-called Alzheimer's disease is a devastating neurodegenerative disease that occurs mostly in middle-aged and elderly people, with an average of 5 to 8 patients per 100 people over the age of 60, and as the world ages This number is still increasing exponentially.”

"Unfortunately, more than half of the world's population is unaware of this disease. Against the backdrop of rapid advances in medical care around the world, Alzheimer's disease has become the only disease with an increasing mortality rate in the past decade."

As Chen Chen spread his hands, the reports from various newspapers and periodicals were continuously displayed on the big screen behind him.

The numbers in these reports are staggering.

"Alzheimer's disease, here I call it AD for short, I believe some of you already know it well. After all, it has only two main complications: Aβ protein deposition and Tau protein mutation."

"But until we investigate deeply, we will find that the clues inside are extremely complicated. Behind the two complications, there are countless factors at work, like endless tangled threads..."

Chen Chen pointed to the screen behind him, "So far, the most in-depth discovery in the academic world is probably microglia. As a type of brain immune cells, experiments have shown that microglia can effectively phagocytose Aβ after being activated. protein and abnormal Tau protein, inhibit AD disease."

"But at the same time, this immune cell is a double-edged sword."

Chen Chen turned around, several research reports were displayed on the screen behind him, "Recent studies have shown that microglia not only engulf abnormal proteins, but also secrete a substance called apolipoprotein E, or ApoE. "

"And the gene responsible for secreting ApoE has three conformations, ApoE2, ApoE3 and ApoE4. Each person's body has two pairs of this protein gene, and each person can only have one or two of them."

A list automatically appeared behind Chen Chen, "In other words, the chance of your gene combination in everyone's body is about one in six."

"ApoE was originally supposed to help remove Aβ deposits, but in subsequent studies, scientists found that E2 was more effective than E3, while E4 had the opposite effect, aggravating Aβ deposits."

"Having a copy of the E4 gene will increase the risk of AD by 3 times, and if the gene sequence in your body is [E4/E4], then congratulations, your risk of developing AD is 12 times that of ordinary people."

Following Chen Chen's words, there was a whisper of chatter from the audience.

"Microglia have an effect not only on Aβ protein deposition, but also on Tau protein mutations."

Chen Chen spread his hands, "Tau protein phosphorylation mutation will lead to neurofibrillary tangles, which will lead to the death of nerve cells, but how does this death happen?"

"What we now find is that this death may still be caused by microglia, which, while attacking those tangles, damage nearby neurons, and that APOE4 secreted by microglia also amplifies Tau Toxicity of neurons."

"So, after genetically identifying a patient, can we restrict or activate microglia based on the patient's genes?"

Chen Chen followed suit, "And my Black Light Biological Research Center is based on this."

Several old people in the audience looked at each other and nodded approvingly.

Chen Chen uploaded the document photo in his hand to the projector, "In AD complications, there is always inflammation, and in a recent study, it was found that a cytokine called IL-1β can cause an inflammatory response, and IL-1β can cause inflammation. The increase in 1β cytokines is due to the sharp decrease in TOM1 protein…”

"The paper published in "PNAS" confirmed this point of view. After the expression of TOM1 decreased, the Aβ protein in the brains of AD model mice did increase, and the cognitive ability of these mice also declined. "

"So, during my experiment, I activated the TOM1 protein gene by gene overexpression, which greatly improved the condition of the experimental subjects."

Chen Chen uploaded the experimental materials one by one, "Everyone can think of TOM1 as the brake structure of a car, but in the brains of AD patients, this brake fails, and what we need to do is to repair this brake at the molecular level."

When everyone heard the words, their expressions moved.

"Through the first two methods, we have temporarily suppressed the disease of AD, but if we don't look for a solution, the result will still be a tragedy. Then what we need to do next is to eliminate the deposition."

"So, the third project in our research center, developed by Eli Lilly, is a monoclonal antibody against the Aβ peptide chain, preventing its deposition, causing aggregation, and eliminating it from the human brain."

"Of course, this is not enough, so we have the last and most important process - to create autologous neural stem cells by means of 'induced pluripotent stem cells', while activating the G2 quiescent stem cells of the human brain."

"In this way, we can restore the brains of AD patients, if not to the original state, but to a large extent."

Following Chen Chen's words, photos and evidence after animal experiments appeared on the screen, and everyone in the audience finally couldn't help and began to discuss in a low voice.

"These results will be published in "CELL" in the future. If you are interested, you can contact me, and I can provide you with detailed data."

With that said, Chen Chen turned off the projector, turned around and walked off the podium.

clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap clap...

The crowd burst into applause.

Seeing this scene, Chen Chen couldn't help but think of the scene when Professor Wang Xi gave him a lecture.

More than a year ago, I was still sitting in a university class, listening to Professor Wang Xi driving a train, constantly instilling some forward-looking remarks into my group of students.

At that time, the goal of many people's life was to become an academic giant like Professor Wang Xi in twenty or thirty years' time, right?

But I didn't expect that just over a year later, I would stand on a nearly equal position with Professor Wang Xi.

However, this is just the beginning...

Chen Chen thought silently.